Articles

June 9, 2018

FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion

Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion Background: A novel formulation of bosentan was evaluated […]
May 19, 2018

An Approach to Pulmonary Arterial Hypertension

An Approach to Pulmonary Arterial Hypertension in the Adult Patient With Congenital Heart Disease Pulmonary arterial hypertension in adult patients with congenital heart disease is a heterogeneous condition caused by pulmonary vascular disease, pulmonary vasoconstriction or by overcirculation. These pathophysiologies may […]
May 19, 2018

Treatment of Opioid Dependence With Buprenorphine/Naloxone

Treatment of Opioid Dependence With Buprenorphine/Naloxone After Liver Transplantation: Report of Two Cases Opioid dependence is an increasing public health problem. One of the complications of intravenous opioid […]
May 1, 2018
Effect of Bosentan on Pulmonary Hypertension

Effect of Bosentan on Pulmonary Hypertension

 Effect of Bosentan on Pulmonary Hypertension Secondary to Systolic Heart Failure ABSTRACT Objectives: The dual endothelin receptor antagonist bosentan improves pulmonary vascular resistance (PVR) in patients with […]
April 16, 2018

Plasma Concentration of Oxycodone

Plasma Concentration of Oxycodone and Pain during Hemodialysis in a Patient with Cancer ABSTRACT Pain is one of the most common problems in palliative medicine, and […]
March 10, 2018
Analgesic plasma concentrations of oxycodone

Analgesic plasma concentrations of oxycodone

Analgesic plasma concentrations of oxycodone after surgery for breast cancer ABSTRACT We investigated factors affecting analgesic oxycodone concentrations after breast cancer surgery in 1,000 women. Preoperatively, […]
March 10, 2018
Development of Bosentan

Pediatric Development of Bosentan

Pediatric Development of Bosentan Facilitated by Modeling and Simulation ABSTRACT Background Bosentan is approved for use in adult patients with pulmonary arterial hypertension. The primary aim of the pharmacokinetic […]
February 27, 2018
Buprenorphine compared with methadone

Buprenorphine compared with methadone

Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: systematic review and meta-analysis of safety in the mother, fetus and child  Running head: Buprenorphine […]
February 26, 2018
New Pain Management

New Pain Management

New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine ABSTRACT Perioperative management of patients receiving opioid addiction therapy presents a unique challenge for the anesthesiologist. […]
February 14, 2018
Cancer Pain Treated

Cancer Pain Treated

Cancer Pain Treated with Rectally Administered Prolonged-elease Oxycodone Hydrochloride Tablets ABSTRACT The aim of this study was to evaluate the effectiveness of opium tincture versus methadone syrup in […]
February 6, 2018

Opium tincture versus methadone syrup

Opium tincture versus methadone syrup in management of acute raw opium withdrawal: A randomized, double-blind, controlled trial ABSTRACT The aim of this study was to evaluate […]
January 15, 2018

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn

Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo- Controlled Exploratory Trial Objective To evaluate the efficacy, safety, […]
January 15, 2018

A Comparison of Echocardiographic

A Comparison of Echocardiographic Variables of Right Ventricular Function with Exercise Capacity After Bosentan Treatment in Patients with Pulmonary Arterial Hypertension: Results from a Multicenter, Prospective, Cohort Study ABSTRACT: […]
August 27, 2017

Buprenorphine for the Treatment of Opioid Dependence

Buprenorphine has been available as a prescription opioid in Canada since 2008. It is marketed as Suboxone® by RB Pharmaceuticals in ombination with naloxone in a […]
August 2, 2017

National Guidelines for Medication-Assisted Treatment of Opioid Dependence

The age of first use, route of administration and individual response to drug user are all factors that influence the likelihood of initial drug use progressing […]
July 23, 2017

Methadone and buprenorphine for the management of opioid dependence

1.1Methadone and buprenorphine (oral formulations), using flexible dosing regimens, are recommended as options for maintenance therapy in the management of opioid dependence. 1.2The decision about which drug […]
July 11, 2017

Use of Oxycodone in Pain Management

Oxycodone is widely used to alleviate moderate-to severe acute pain, It is an effective analgesic for many types of pain, and is especially useful for paroxysmal […]
July 9, 2017

Opioid Dependence Treatment and Guidelines

In response to the increased incidence of opioid abuse, the large degree of variance in patterns for prescribing opioids, and the many different medical specialties involved in […]
July 3, 2017

Flexible dosing of Tincture of Opium in the management of opioid

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT In parts of South-East Asia, Tincture of Opium (TOP) is a culturally acceptable alternative to methadone in the treatment […]
June 24, 2017

Substitute Prescribing for Opioid Dependence

Aims and benefits of treatment The aims of prescribing for opioid dependence are to: Reduce or prevent withdrawal symptoms. Provide an opportunity to stabilise drug intake […]
EnglishIran