Buprenorphine compared with methadone to treat pregnant women with opioid use disorder:
systematic review and meta-analysis of safety in the mother, fetus and child
Running head: Buprenorphine safety during pregnancy
To assess the safety of buprenorphine compared with methadone to treat pregnant women
with opioid use disorder.
We searched PubMed, Embase and the Cochrane Library from inception through February 2015 for randomized controlled trials (RCT) and observational cohort studies (OBS) that compared buprenorphine with methadone for treating opioid-dependent pregnant women. Two reviewers independently assessed titles and abstracts of all search results and full texts of potentially eligible studies reporting original data for maternal/fetal/infant death, preterm birth, fetal growth outcomes, fetal/congenital anomalies, fetal/child neurodevelopment, and/or maternal adverse events. We ascertained each study’s risk of bias using validated instruments and assessed the strength of evidence for each outcome using established methods. We computed effect sizes using random-effects models for each
outcome with 2 or more studies.