Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion Background: A novel formulation of bosentan was evaluated […]
Treatment of Opioid Dependence With Buprenorphine/Naloxone After Liver Transplantation: Report of Two Cases Opioid dependence is an increasing public health problem. One of the complications of intravenous opioid […]
Plasma Concentration of Oxycodone and Pain during Hemodialysis in a Patient with Cancer ABSTRACT Pain is one of the most common problems in palliative medicine, and […]
Analgesic plasma concentrations of oxycodone after surgery for breast cancer ABSTRACT We investigated factors affecting analgesic oxycodone concentrations after breast cancer surgery in 1,000 women. Preoperatively, […]
Pediatric Development of Bosentan Facilitated by Modeling and Simulation ABSTRACT Background Bosentan is approved for use in adult patients with pulmonary arterial hypertension. The primary aim of the pharmacokinetic […]
Buprenorphine compared with methadone to treat pregnant women with opioid use disorder: systematic review and meta-analysis of safety in the mother, fetus and child Running head: Buprenorphine […]
New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine ABSTRACT Perioperative management of patients receiving opioid addiction therapy presents a unique challenge for the anesthesiologist. […]
Cancer Pain Treated with Rectally Administered Prolonged-elease Oxycodone Hydrochloride Tablets ABSTRACT The aim of this study was to evaluate the effectiveness of opium tincture versus methadone syrup in […]
Opium tincture versus methadone syrup in management of acute raw opium withdrawal: A randomized, double-blind, controlled trial ABSTRACT The aim of this study was to evaluate […]
Bosentan as Adjunctive Therapy for Persistent Pulmonary Hypertension of the Newborn: Results of the Randomized Multicenter Placebo- Controlled Exploratory Trial Objective To evaluate the efficacy, safety, […]
A Comparison of Echocardiographic Variables of Right Ventricular Function with Exercise Capacity After Bosentan Treatment in Patients with Pulmonary Arterial Hypertension: Results from a Multicenter, Prospective, Cohort Study ABSTRACT: […]
The age of first use, route of administration and individual response to drug user are all factors that influence the likelihood of initial drug use progressing […]
1.1Methadone and buprenorphine (oral formulations), using flexible dosing regimens, are recommended as options for maintenance therapy in the management of opioid dependence. 1.2The decision about which drug […]
In response to the increased incidence of opioid abuse, the large degree of variance in patterns for prescribing opioids, and the many different medical specialties involved in […]
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT In parts of South-East Asia, Tincture of Opium (TOP) is a culturally acceptable alternative to methadone in the treatment […]
Aims and benefits of treatment The aims of prescribing for opioid dependence are to: Reduce or prevent withdrawal symptoms. Provide an opportunity to stabilise drug intake […]
Role of buprenorphine in acute postoperative pain Utilidad de la buprenorfina en el dolor agudo postoperatorio Abstract Nowadays acute postoperative pain persists as a high prevalence […]
Overview An estimated 69 000 people die each year from opioid overdose. Opioid overdose is easily reversed with the opioid antidote naloxone and with basic life […]
Body Composition Changes Associated With Methadone Treatment Background: Methadone is associated with a statistically significant increase in BMI in the first 2 years of treatment. Objectives: […]
Maintenance Therapy with Opium Tincture for Injecting Drug Users; Implications for Prevention from Viral Infections Viral infections such as HIV and HCV have a serious negative […]
Susceptibility Does Not Mean Inevitability When scientists look for “addiction genes,” what they are really looking for are biological differences that may make someone more or […]