Hyoscine
Introduction
Hyoscine manufactured by Faran Shimi Pharmaceutical Company,is supplied in 10mg hyoscine N-Butyl bromide. 10 tablets are packed in a blister and 10 blisters are packaged in one box with a leaflet.
Indications
Gastrointestinal/genitourinary spasm:
• Treatment of abdominal spasms and pain and discomfort in the stomach, bowels, and biliary tract.• Prevention of spasm prior to radiological or diagnostic procedures.
• May also be used off label for management of pain associated with smooth muscle spasms in the urinary tract.
• Prevention of nausea and vomiting associated with motion sickness.
• Prevention of postoperative nausea and vomiting associated with recovery from anesthesia or opioid analgesia and surgery.
Use: Off-Label: Adult
Malignant bowel obstruction, inoperable; Sialorrhea; Terminal airway secretions (death rattle)Important Information
Dosing
Adults
Hyoscine Butyl bromide: Oral: 10 to 20 mg 3 to 5 times/day as needed.
Note: When used for chronic symptom control, 10 mg 3 to 5 times/day as needed is recommended.
Maximum: 60 mg/day
Renal Impairment: (Adult)
Has not been studied, caution is recommended due to increased risks of adverse effects.
Hepatic Impairment: (Adult)
Has not been studied, caution is recommended due to increased risks of adverse effects.
Geriatric:
No specific information on the use of this product in the elderly is available.Clinical trials have included patients over 65 years and no adverse reactions specific to this age group have been reported.
Pediatric
Children 6 - 12 years: 1 tablet three times daily.• Perennial
Children ≥6 years and Adolescents <15 years: Oral: 5 mg once daily
Hyoscine 10 mg Tablets should not be taken on a continuous daily basis or
for extended periods without investigating the cause of abdominal pain.
Administration:
Hyoscine 10 mg Tablets are for oral administration only and
should be swallowed whole with adequate water.
Interactions
The anticholinergic effect of drugs such as tri- and tetracyclic antidepressants,
antihistamines, quinidine, amantadine, antipsychotics (e.g. butyrophenones, phenothiazines),
disopyramide and other anticholinergics (e.g. tiotropium, ipratropium, atropine-like compounds) may be intensified by Hyoscine.
Concomitant treatment with dopamine antagonists such as metoclopramide may result in diminution
of the effects of both drugs on the gastrointestinal tract.
The tachycardic effects of beta-adrenergic agents may be enhanced by Hyoscine.
Pregnancy
Hyoscine crosses the placenta.There are limited data from the use of hyoscine butylbromide in pregnant women.Animal studies are insufficient with respect to reproductive toxicity. As a precautionary measure Hyoscine is not recommended during pregnancy.
Breast-Feeding
Hyoscine is present in breast milk.
The decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant,
and benefits of treatment to the mother. The Academy of Breastfeeding Medicine (ABM) states that Hyoscine used
as an antiemetic in the perioperative period is likely safe; however, because Hyoscine may cause maternal sedation
and adversely affect milk supply with repeated doses, other agents may be preferred.
Contraindications
Hypersensitivity to hyoscine butylbromide, atropinics, or any component of the formulation;
glaucoma, megacolon, mechanical stenosis in the GI tract, myasthenia gravis, obstructive prostatic hypertrophy, paralytic or obstructive ileus.
Warnings/Precautions
Hyoscine 10 mg Tablets should be used with caution in conditions characterised by tachycardia such as thyrotoxicosis,
cardiac insufficiency or failure and in cardiac surgery where it may further accelerate the heart rate. Due to the risk of
anticholinergic complications, caution should be used in patients susceptible to intestinal or urinary outlet obstructions.
Because of the possibility that anticholinergics may reduce sweating, Hyoscine should be administered with caution to patients with pyrexia
Elevation of intraocular pressure may be produced by the administration of anticholinergic agents such as Hyoscine in patients with
undiagnosed and therefore untreated narrow angle glaucoma. Therefore, patients should seek urgent ophthalmological advice in
case they should develop a painful, red eye with loss of vision whilst or after taking Hyoscine.
Side Effects
• Dry mouth• Abnormal sweating or reduced sweating
• Increased heart rate
• Being unable to pass water (urine)
