Opium Tincture

Opium 1%


Introduction

Opium tincture belongs to the same class of medicines as the narcotic pain relievers. Each 5mL Opium tincture contains 50mg of morphine. Opium tincture _Manufactured by Faran Shimi Pharmaceutical Company_ is supplied as Bottles of 250ml that are packaged in one box with a leaflet.

Indications

Opium is indicated for the treatment of diarrhea in adults. It results in a decrease in digestive secretions, an increase in GI muscle tone, and therefore a reduction in GI propulsion.
On the other hand, there has been more regards for the use of opium tincture for detoxification and maintenance treatment of opioid dependence.

Important Information

Dosing

Adults:
For use as a maintenance treatment, the dose is determined by the physician based on the patient's condition.
Diarrhea: Oral: 6mg (0.6mL) of undiluted opium tincture (10mg/mL) 4 times daily.
Renal Impairment:
No dosage adjustment necessary.

Hepatic Impairment:
No dosage adjustment necessary. Use with caution.

Administration

May administer with food to decrease GI upset.

Major Interactions (Risk X)

Azelastine (Nasal), Eluxadoline, Opioids (Mixed Agonist /Antagonist), Orphenadrine, Oxomemazine, Paraldehyde, Thalidomide.

Pregnancy

Morphine crosses the placenta. Maternal use of opioids may be associated with birth defects, poor fetal growth, stillbirth, and preterm delivery. The alcohol content should also be taken into consideration in pregnant women. Use is not recommended.

Breast-Feeding

Morphine is present in breast milk. The alcohol content should also be taken into consideration. Use with caution.

Contraindications & Cautions

Contraindications

Use in children; diarrhea caused by poisoning until the toxic material is eliminated from the GI tract.

Warnings/Precautions

CNS depression: may impair physical or mental abilities; patients must be cautioned about performing tasks which require mental alertness (e.g., operating machinery or driving).
Hypotension: use with caution in patients with hypovolemia, cardiovascular disease (e.g., acute MI), or with drugs which may exaggerate hypotensive effects (phenothiazines or general anesthetics).
Adrenocortical insufficiency (e.g., Addison disease): Use with caution.
Biliary tract impairment (e.g., acute pancreatitis): Use with caution.
GI Hemorrhage: Use with caution in patients with GI hemorrhage.
Head trauma: Use with extreme caution in patients with head injury, intracranial lesions, or elevated intracranial pressure (ICP); exaggerated elevation of ICP may occur.
Obesity: Use with caution in patients who are morbidly obese.
Prostatic hyperplasia/urinary stricture: Use with caution.
Thyroid dysfunction: Use with caution.
Hepatic impairment: Use with caution.
Drug abuse: Use with caution in patients with a history of drug abuse or acute alcoholism.

Side Effects

Cardiovascular: Bradycardia, hypotension, palpitations, peripheral vasodilation.
Central nervous system: CNS depression, depression, dizziness, headache, increased intracranial pressure, insomnia, malaise, restlessness.
Gastrointestinal: Anorexia, biliary tract spasm, constipation, nausea, stomach cramps, vomiting.
Genitourinary: Decreased urine output, genitourinary tract spasm.
Hypersensitivity: Histamine release
Neuromuscular & skeletal: Weakness
Ophthalmic: Miosis
Respiratory: Respiratory depression
Iran